Ofloxacin belongs to the flouroquilone class and has antibacterial properties. It shows bactericidal activity against both gram-negative and gram-positive bacteria. It has 100 times more affinity towards the enzyme DNA gyrase.
Treatment of gonorrhoea
Syphilis
Cervicitis
Conjunctivitis
In bacterial infections
Community acquired anemia
Prostatis
Traveller’s diarrhoea
Ofloxacin inhibits the enzyme DNA gyrase which is responsible for supercoiling of the One strand of DNA to other during replication or known as transcription.
Absorption- It is absorbed by oral route
Protein Binding- It is 32% bound to plasma proteins
Metabolism- It is metabolized in the liver
Excretion- It is excreted via urine
Nausea
Vomiting
Constipation
Gas
Vomiting
Cramps in the stomach
Changes in ability to taste food
Loss of appetite
Contraindicated in myasthenia gravis Contraindicated in people with low blood sugar
Warfarin
Amiodarone
Quinidine
Sotalol
Dofetilide
| Ofloxacin | 200 mg |