Ofloxacin is an antibiotic of fluoroquinolone family of medications useful for the treatment of a number of bacterial infections. It works by interfering with the bacterium's DNA, halting DNA replication. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Pneumonia
Cellulitis
Urinary tract infections
Prostatitis
Plague
Infectious diarrhea
Multidrug resistant tuberculosis
DNA replication requires DNA gyrase and topoisomerase IV. DNA gyrase allows the untwisting required to replicate one DNA double helix into two. Topoisomerase IV provides stability to the unwind DNA during replication. Ofloxacin inhibits these two and inhibit DNA replication thereby inhibits normal cell division.
It is well orally absorbed with the bioavailability of 98% and protein binding is 32%. It is mainly metabolised in liver and 65% to 80% of an administered oral dose of ofloxacin is excreted unchanged via urine within 48 hours of dosing. About 4-8% is excreted in feces. The half-life of ofloxacin is 9 hours.
Vomiting
Diarrhea
Headache
Rash
Tendon rupture
Numbness due to nerve damage
Seizures
Psychosis
Following drugs may interact with ofloxacin:
Aspirin
Azithromycin
Dexamethasone
Erythromycin
Metformin
Warfarin
Procainamide
Amiodarone
Quinidine
| Ofloxacin USP | 50 mg |