The composition of ofloxacin and metronidazole which works by preventing the repairing and division of the bacteria .Also, it kills the parasites and anaerobic bacteria that causes infections by affecting their DNA.
Pneumonitis
Urinary tract infections
Prostatitis
It also treats diarrhoea
Gonorrhoea
Useful in urethral infections
Metronidazole undergoes reduction and this reduction usually occurs in bacteria and protozoans therefore they inhibit nucleic acid synthesis by causing disruption of DNA.
Ofloxacin inhibits the enzyme topoisomerase 4 and DNA gyrase, DNA gyrase is required for the transcription, repair and replication of DNA.
Metronidazole-
It is absorbed orally
It is 20% bound to serum proteins
It undergoes oxidation and glucuronidation
It is excreted via urine
Numbness
Tingling
Dizziness
Nausea
Increased heart rate
Tingling
Burning sensation
Metformin
Metronidazole
Ibuprofen
Doxycycline
| Ofloxacin USP | 50 mg |
| Metronidazole | 120 mg |