Pregabalin is similar in structure with gamma-aminobutyric acid (GABA), it does not bind to GABA receptors. Pregabalin works by binding to the alpha2-delta subunit present presynaptically which are voltage-gated calcium channels in the central nervous system. Alpha2-delta is present on presynaptic nerve which is the subunit of voltage-gated calcium channels in the central nervous system, pregabalin modulates the release of several excitatory neurotransmitters including glutamate, substance-P, norepinephrine, and calcitonin gene related peptide. Pregabalin has no effect on dopamine receptors, serotonin receptors, opiate receptors, sodium channels or cyclooxygenase activity.

Vitamin B12 or Methylcobalamin deficiency has been associated with significant neurological pathology, especially peripheral neuropathy. Methylcobalamin is a coenzyme form (that helps to catalyze the reactions) that acts as an important co-factor in the activities of vitamin B12-dependent methyltransferases. It helps in maintaining the integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis. Methylcobalamin promotes neuronal lipids synthesis, regeneration of axonal nerves and has neuroprotective activity, which promote neurons to function in proper way.

Dizziness
Drowsiness
Dry mouth
Constipation