Itraconazole belongs to triazole and imidazole antifungal drug. It is used by immunocompromised and non-immunocompromised patients. it interacts with the membrane phospholipids thus inhibits the endogenous respiration. It also prevents the transformation of yeast into the mycelial cells. The drug accumulates in the fungi which is responsible for its fungicidal action.
Blastomycosis
Histoplasmosis
Aspergillosis
Onychomycosis
Itraconazole inhibits the cytochrome P450 enzymes i.e. 14 alpha demethylase which is responsible for the conversion of ergosterol into lanosterol. ergosterol here is the component of fungal cell membrane.
Absorption- It is absorbed orally
Protein Binding- It is 99% bound to proteins
Metabolism- It undergoes oxidation and dealkylation
Excretion- It is excreted via urine
Headache
Dizziness
Drowsiness
Rashes
Nausea
Vomiting
Stomach pain
Contraindicated in chronic heart failure
Contraindicated in kidney disorders
Rifampin
Phenytoin
Carbamazepine
Phenobarbital
| Itraconazole | 200 mg |