Rabeprazole decreases gastric acid production. Rabeprazole may also be used with other antibiotics in H. pylori infection along that are associated with gastric ulcers. Rabeprazole inhibits proton pump irreversibly and is very selective and hence suppresses gastric acid secretion by particularly inhibition of the H+, K+ -ATPase, which is found at the secretory surface of parietal cells.

Domperidone is a specific blocker of dopamine receptors. It increases peristaltic moment, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Domperidone improvess gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Domperidone works by blocking D2 and D3 dopamine receptors present in CTZ (chemoreceptor trigger zone) and shows antiemetic property. It is more selective for the receptors which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting.