This is an ideal dietary supplement for people with knee pain and is a remarkable example of nutritional science – being a delicately balanced formula to improve bone and joint health and combating debilitating bone-joint diseases. This is a perfect combination which contains Calcitriol, Calcium Carbonate, and Zinc as active ingredients. The components in combination are helping body in Low blood calcium levels in people who do not get enough calcium from their diets Conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). Certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone). Neutralizing acids thus relieving acid reflux Regulating the intestinal fluid transport, mucosal integrity, immunity, gene expression and oxidative stress along with taking care of body's normal growth and its repair.
Bone diseases in renal osteodystrophy
Dietary supplement
Bones weakening
Better absorption
Acidity & Heartburn
Stomach ulcer
Diarrhea
Wilson's disease
Acne
Age related vision loss
Anemia
Calcitriol, a pharmaceutical form of vitamin D, has anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities. Calcitriol has been found to be effective in the treatment of psoriasis when applied topically. Calcitriol has been found to induce differentiation and/or inhibit cell proliferation in a number of malignant cell lines including human prostate cancer cells. Vitamin D deficiency has long been suspected to increase the susceptibility to tuberculosis. The active form of calcitriol, 1,25-(OH)2-D3, has been found to enhance the ability of mononuclear phagocytes to suppress the intracellular growth of Mycobacterium tuberculosis. 1,25-(OH)2-D3 has demonstrated beneficial effects in animal models of such autoimmune diseases as rheumatoid arthritis. It has also been found to induce monocyte differentiation and to inhibit lymphocyte proliferation and production of cytokines, including interleukin IL-1 and IL-2, as well as to suppress immunoglobulin secretion by B lymphocytes. Vitamin D appears to demonstrate both immune-enhancing and immunosuppressive effects.
Calcium is needed for so many different functions in the body, from bones, to blood clotting, your muscles etc. It is an essential mineral that provides strength to bones and teeth, but it has several other health benefits. Calcium is essential to nerve conduction, hormone status and muscle contraction. Some research has shown that diets rich in calcium, fruits and vegetables can reduce the risk of high blood. Calcium helps the body form bones and teeth and is required for blood clotting, transmitting signals in nerve cells, and muscle contraction. Calcium helps prevent osteoporosis; of the two to three pounds of calcium contained in the human body, 99% is located in the bones and teeth. Calcium reduces the risk of osteoporosis.
Zinc is a trace mineral and it is essential for many bodily functions including the immune response, reproduction, growth and development, and neurological roles. It is found in several systems and biological reactions, and it is needed for immune function, wound healing, blood clotting, and thyroid function. Zinc is not only important for enzymes but also for proteins and amino acid syntheses. It is involved in learning, memory formation, cellular signalling, gene expression and the metabolism of DNA and RNA. Zinc makes up a small percentage of the bone; zinc is needed to form hydroxylapatite which is a naturally occurring crystalline calcium complex. Hydroxylapatite crystals form the bulk of bones and teeth. Zinc can also improve bone health indirectly by other means. For example, zinc promotes wound healing and enhances the functions of the immune system.
Calcitriol:
ABSORPTION:Calcitriol is rapidly absorbed from the intestine. Peak serum concentrations following a single oral dose of 0.25-1µg Rocaltrol in healthy subjects were found within 2-6 hours.
DISTRIBUTION:During transport in the blood at physiological concentrations, calcitriol is mostly bound to a specific vitamin D binding protein (DBP), but also, to a lesser degree, to lipoproteins and albumin.
METABOLISM:Calcitriol is hydroxylated and oxidised in the kidney and in the liver by a specific cytochrome P450 enzyme: CYP24A1.
ELIMINATION:The elimination half-life of calcitriol in plasma ranges between 5 to 8 hours.
Calcium Carbonate:
ABSORPTION:Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.
VOLUME OF DISTRIBUTION:Calcium is rapidly distributed taken up by skeletal tissues following absorption and distribution into extracellular fluids. Bone contains 99% of the body's calcium and the remaining 1% is approximately equally distributed between intracellular and extracellular fluids.
PROTEIN BINDING:Calcium acts as a co-factor to numerous enzymes.
ROUTE OF ELIMINATION:Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.
Zinc:
ABSORPTION:Approximately 20 to 30% of dietary zinc is absorbed, primarily from the duodenum and ileum. After absorption, zinc is bound in the intestine to the protein metallothionein. Endogenous zinc can be reabsorbed in the ileum and colon, creating an enteropancreatic circulation of zinc.
PROTEIN BINDING:Zinc is 60% bound to albumin; 30 to 40% bound to alpha-2 macroglobulin or transferrin; and 1% bound to amino acids, primarily histidine and cysteine.
ROUTE OF ELIMINATION:Primarily fecal (approximately 90%); to a lesser extent in the urine and in perspiration.
Diseases and/or conditions resulting in hypercalcaemia and/or hypercalciuria (e.g. myeloma, bone metastases, primary hyperparathyroidism)
Nephrolithiasis / nephrocalcinosis
Severe renal impairment and renal failure
Hypervitaminosis D
| Calcitriol IP | 0.25 mcg |
|
Calcium Carbonate IP (Eq. to Elemental Calcium 200mg) |
500 mg |
| Zinc (As Zinc Sulphate Monohydrate) IP | 7.5 mg |