Cefixime and Ofloxacin is a combination of two antibiotics: Cefixime and Ofloxacin. Cefixime acts by preventing the formation of the bacterial protective covering which is essential for the survival of the bacteria in the human body. Ofloxacin shows its action by resisting the bacteria from reproducing and repairing themselves. Together, they treat your infection effectively.
Tonsillitis
Pharingitis
Bronchitis
UTI
Gonorrhea
Infections caused by susceptible bacterias
Cefixime exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime also inhibits transpeptidase and prevents cross linking of bacterial cell wall. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens and Streptococcus pneumonia and many beta lactamase producing bacteria.
Ofloxacin shows its action by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4. DNA gyrase assists in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein.
Cefixime:
Absorption: It is absorbed orally up to 50 % & food delays absorption.
Distribution: widely distributed.
Metabolism: A part of drug is metabolized in the body.
Excretion: Excreted mainly through urine.
Half Life of Cefixime: 3 hour
Ofloxacin:
Absorption: Ofloxacin is absorbed rapidly and completely after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Half Life of Ofloxacin: 5 - 8 hours
Nausea
Vomiting
Diarrhea
Stomach pain
Indigestion
Flatulence
Hypersensitivity to cephalosporins
Hypersensitivity to Ofloxacin and other Fluoroquinolones
You are advised to take this drug with food to avoid stomach upset.
Take this medication as prescribed dose and duration as advised by your physician.
Consult your doctor if you have or had any previous history of heart, kidney or liver diseases.
You may experience dizziness, drowsiness, tiredness or any visual disturbances, so avoid driving and using machinery.
This drug may make you dizzy or drowsy. Consumption of alcohol can make you even more dizzy or drowsy.
Do not take this medication if you are allergic or experience skin rash or swelling of the face or throat.
| Cefixime | 200 mg |
| Ofloxacin | 200 mg |