Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid.
Gastroesophageal reflux disease
Peptic ulcers
Helicobacter pylori Infections
Duodenal ulcers
Omeprazole inhibits the sodium potassium ATPase pump present on the parietal cells. secretion of hydrochloric acid is mediated by this pump.
Absorption-
It is rapidly absorbed by gastrointestinal tract
Protein binding-
It is 95% bound to plasma proteins
Metabolism-
It is metabolized in the liver
Excretion–
It is excreted unchanged via urine
Headache
Stomach pain
Diarrhoea
Gas
Vomiting
Fever in children
Contraindicated in people with known hypersensitivity
Diazepam
Warfarin
Phenytoin
Ampicillin
| Omeprazole IP | 20 mg |