This product contains pantoprazole and domperidone which is used to prevent over secretion of gastric acid. gastric acid hypersecretion causes many diseases such as gastroesophageal reflux disease or increases the risk of ulcers or bleeding of gastrointestinal tract.
Gastroesophageal reflux diseases
Zollinger-elision syndrome
Heartburn
Stress ulcers
Bacterial infections due to H. pylori
Pantoprazole blocks the Na+K+ATPase pump present on the parietal cells it does it so by binding with the sulfhydryl groups of cysteine of the pump and decreases the acid secretion.
Domperidone blocks the d1 and d2 receptors present at the chemotrigger zone which is located outside the blood brain barrier and helps to treat nausea and vomiting.
Pantoprazole-
It is absorbed orally
It is 98% bound to plasma proteins
It is metabolized in the liver
It is excreted via feces
Domperidone-
It is 91-93% bound to proteins
Dry mouth
Abdominal cramps
Diarrhoea
Nausea
Rashes
Contraindicated in people with congestive heart failure
Contraindicated in systemic lupus erythematous
Digoxin
Indinavir
Itraconazole
| Pantoprazole Sodium IP | 40 mg |
| Domperidone IP | 30 mg |