This is a combination contains Domperidone and Pantoprazole. Domperidone is a prokinetic which works on the upper digestive tract to increase the peristaltic movement, allowing the food to move more easily through the stomach. Pantoprazole is a proton pump inhibitor (PPI) act by inhibiting production of gastric acid in the stomach which helps in the relief of acid-related indigestion and heartburn.
Gastroesophageal reflux disease (GERD)
Zollinger-Ellison Syndrome
Peptic ulcer
Erosive Esophagitis (EE)
Bacterial Infection Due to Helicobacter Pylori
Pantoprazole is benzimidazole derivatives. It inhibits gastric acid secretion for a longer duration. H(+)/K(+)-ATPase of the proton pump secrets hydrochloric acid (HCl) secretion into the gastric lumen, expressed in high quantities by the parietal cells of the stomach. Parietal cell membrane contains ATPase an enzyme that facilitates hydrogen and potassium exchange through the cell, which normally results in the extrusion of potassium and formation of HCl (gastric acid). The active form then makes disulfide bonds with important cysteines on the gastric acid pump, inhibiting its function. The enzyme is inactivated, inhibiting gastric acid secretion.
Domperidone is a specific blocker of dopamine receptors. It increases peristaltic moment, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Domperidone blocks D2 and D3 dopamine receptors present in chemoreceptor trigger zone and shows antiemetic property. It has strong affinities for the, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting.
Pantoprazole is well orally absorbed with bioavailability of 77%. The volume of distribution is 11.0-23.6 L and is 98% bound to plasma protein. It is mainly metabolised in liver by CYP enzymes. About 71% is excreted in urine and 18% is excreted in feces. The half-life of pantoprazole is 1 hour.
Domperidone is rapidly absorbed from GIT and the bioavailability is only 20% due to high first pass metabolism. 91%-93% of the dose administered is bound to plasma protein with a half-life of 7 hours. The metabolites are mainly excreted in urine and feces.
Common side effect includes:
Diarrhea
Stomach pain
Flatulence
Dryness in mouth
Dizziness
Headache
Carefully use in patients with renal and hepatic impairment.
Not to be used in children below 12 years.
Hypersensitivity can occur in patient with phaeochromocytoma.
| Pantaprazole | 40 mg |
| Domperidone | 10 mg |