The combination is used to relieve pain and fever. Diclofenac and serratiopeptidase act as antipyeretic, analgesic and anti-inflammatory. Diclofenac is nonsteroidal anti-inflammatory drugs whereas serratiopeptidase is a proteolytic enzyme.
Muscles Pain
Toothache
Osteoarthritis
Bones And Joints Pain
Joint Pain
Headache
Rheumatoid Arthritis
Fever
Sore Throat
Diclofenac belongs to non-steroidal anti-inflammatory drugs which inhibits cyclooxygenase.
Diclofenac is a phenylacetic acid derivative also inhibiting COX-1 and COX-2 inhibits PG synthesis including PGE2 involved in modulation of nociception or pain sensation.
Serratiopeptidase is an enzyme which works by breaking down abnormal proteins at the site of inflammation and promotes healing.
Diclofenac is well orally absorbed but only 50% is available in plasma due to high first pass metabolism. Volume of distribution for diclofenac was found to be 1.4 L/kg with 99% plasma protein binding. 65% of the dose is excreted in the urine and approximately 35% in the bile. The half-life of diclofenac is 25.8-33 h
Serratiopeptidase is absorbed through the intestines and transported directlyinto the bloodstream. But being a peptide there would be a high propensity of this enzyme to undergo enzymatic degradation in the gastrointestinal tract and low membrane permeability due to the hydrophilic nature of peptides and proteins in general.44,45 So these factors could lead to low bioavailability of this enzyme when used therapeutically. It was seen that the peak concentration in plasma and lymph at a dose of 100 mg/kg were 0.87 0.41 and 43 42 ng/ml, respectively, and this peak plasma concentration was achieved 0.25e0.5 h after the dose and disappeared by 6 h.
Common side effect includes:
Shortness Of Breath
Abdominal Bleeding
Feeling Of Sickness
Stomach Inflammation
Increased Liver Enzymes In Blood
Vomiting
Not be taken along with blood thinners — such as Warfarin
Taking the following tablet with alcohol can cause liver damage
Active peptic ulcer
Should also be avoided by people with hypersensitivity.
| Diclofenac | 50 mg |
| Serratiopeptidase | 10 mg |