Aceclofenac belongs to NSAID’s, showing anti-inflammatory, analgesic and antipyretic effect. It works by inhibiting COX enzyme responsible for producing bad chemical messengers that can lead to fever and pain. It can be used in fever, mild to moderate pain and conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.
Fever
Mild to moderate pain
Rheumatoid arthritis
Ankylosing spondylitis
Osteoarthritis
Aceclofenac is a NSAID that inhibits both isoforms of COX enzyme, a key enzyme involved in the inflammatory process. Through COX-2 inhibition, aceclofenac downregulates the production of various inflammatory mediators including prostaglandin E2 (PGE2), IL-1β, and TNF from the arachidonic acid (AA) pathway.
Aceclofenac is rapidly and completely absorbed from GIT. Time to reach maximum concentration in plasma is about 1.23-3 hours. It is highly bound protein drug with 99% and the volume of distribution is about 25 L. It is metabolised by CYP enzyme family and 70-80% of the metabolites are excreted in urine with only 20% excreted in feces. The half-life is approximately 4 hours.
There are several advantages of sustained release drug delivery over conventional dosage forms like
Improved patient compliance due to less frequent drug administration
Reduction of fluctuation in steady-state drug levels
Maximum utilization of the drug
Increased safety margin of potent drug
Shorter treatment period.
Common side effect of drugs include:
Vomiting
Stomach pain/epigastric pain
Nausea
Indigestion
Diarrhea
Heartburn
Loss of appetite
Following drugs may interact with Aceclofenac:
Anti-hypertensives
Diuretics
Cardiac glycosides like digoxin
Lithium
Methotrexat
Methotrexate
Mifepristone
Anti-coagulants
| Aceclofenacas Sustained Release) | 200 mg |