Aceclofenac and paracetamol belongs to NSAID’s which shows analgesic and antipyretic effect. It works by inhibiting the COX enzyme which is responsible for producing chemical messengers responsible for fever, pain and inflammation. Consuming more than the recommended dose may lead to gastric problems.
Moderate to high fever
Body ache
Mild to moderate pain.
Aceclofenac is a NSAID that inhibits both isoforms of COX enzyme, a key enzyme involved in the inflammatory process. Through COX-2 inhibition, aceclofenac downregulates the production of various inflammatory mediators including prostaglandin E2 (PGE2), IL-1β, and TNF from the arachidonic acid (AA) pathway.
Paracetamol belongs to non-steroidal anti-inflammatory drugs works by inhibiting cyclooxygenase. Paracetamol is a derivative of acetaminophen and is a weak inhibition of COX-1 and COX-2, further inhibiting prostaglandin synthesis.
Aceclofenac is rapidly and completely absorbed from GIT. Time to reach maximum concentration in plasma is about 1.23-3 hours. It is highly bound protein drug with 99% and the volume of distribution is about 25 L. It is metabolised by CYP enzyme family and 70-80% of the metabolites are excreted in urine with only 20% excreted in feces. The half-life is approximately 4 hours.
Paracetamol is also well orally absorbed and volume of distribution is 1.29 l/kg. Protein binding of paracetamol is very negligible. It is metabolised in liver mainly by CYP enzymes. Paracetamol is mainly excreted in urine with a half-life of 3.6 hours.
Common side effect includes:
Stomach pain
Nausea
Vomiting
Stomach ulcers
Do not use paracetamol in the following conditions:
Caloric undernutrition.
Severe renal impairment.
A condition where the body is unable to maintain adequate blood flow called shock.
Acetaminophen overdose.
Acute inflammation of the liver due to hepatitis C virus.
Following drugs may interact with paracetamol:
Acenocoumarol
Carbamazepine
Fosphenytoin
Lixisenatide
Phenytoin
Warfarin
Zidovudine
| Aceclofenac | 100 mg |
| Paracetamol | 325 mg |