Combination contains Aceclofenac, Paracetamol and Chlorzoxazone showing synergistic action against fever, body ache and muscle pain. Aceclofenac and paracetamol belongs to NSAID’s which shows analgesic and antipyretic effect. It works by inhibiting the COX enzyme which is responsible for producing chemical messengers responsible for fever, pain and inflammation. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort.
Moderate to high fever
Body ache
Mild to moderate pain
Acute painful musculoskeletal conditions
Aceclofenac is a NSAID that inhibits both isoforms of COX enzyme, a key enzyme involved in the inflammatory process. Through COX-2 inhibition, aceclofenac downregulates the production of various inflammatory mediators including prostaglandin E2 (PGE2), IL-1β, and TNF from the arachidonic acid (AA) pathway.
Paracetamol belongs to non-steroidal anti-inflammatory drugs works by inhibiting cyclooxygenase. Paracetamol is a derivative of acetaminophen and is a weak inhibition of COX-1 and COX-2, further inhibiting prostaglandin synthesis.
Chlorzoxazone is a centrally-acting agent for painful musculoskeletal conditions. chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex a.c. involved in producing and maintaining skeletal muscle spasm of varied etiology.
Aceclofenac is rapidly and completely absorbed from GIT. Time to reach maximum concentration in plasma is about 1.23-3 hours. It is highly bound protein drug with 99% and the volume of distribution is about 25 L. It is metabolised by CYP enzyme family and 70-80% of the metabolites are excreted in urine with only 20% excreted in feces. The half-life is approximately 4 hours.
Paracetamol is also well orally absorbed and volume of distribution is 1.29 l/kg. Protein binding of paracetamol is very negligible. It is metabolised in liver mainly by CYP enzymes. Paracetamol is mainly excreted in urine with a half-life of 3.6 hours.
Chlorzoxazone is 13-18% bound to plasma protein. Chlorzoxazone is rapidly metabolized in the liver and is excreted in the urine, primarily in a conjugated form as the glucuronide.
Chlorzoxazone is rapidly metabolized and is excreted in the urine, primarily in a conjugated form as the glucuronide. The half-life of chlorzoxazone is 66 minutes.
Common side effect includes:
Stomach pain
Nausea
Vomiting
Stomach ulcers
Do not use paracetamol in the following conditions:
Caloric undernutrition.
Severe renal impairment.
A condition where the body is unable to maintain adequate blood flow called shock.
Acetaminophen overdose.
Acute inflammation of the liver due to hepatitis C virus.
Following drugs may interact with paracetamol:
Acenocoumarol
Carbamazepine
Fosphenytoin
Lixisenatide
Phenytoin
Warfarin
Zidovudine
Atropine
| Aceclofenac | 100 mg |
| Paracetamol | 325 mg |
| Chlorzoxazone | 250 mg |