Terbinafine hydrochloride is a synthetic allylamine antifungal. Because of its high lipophilicity it accumulates in skin, nails, and fatty tissues. Terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.
Candidiasis, Cutaneous
Onychomycosis
Pityriasis versicolor
Sporotrichosis
Tinea Capitis
Tinea Corporis
Tinea Cruris
Tinea Pedis
Terbinafine is an allylamine antifungal that inhibits squalene epoxidase (also known as squalene monooxygenase) to prevent the formation of ergosterol and cause an accumulation of squalene, weakening the cell wall of fungal cells. This inhibition leads to decreased ergosterol, which would normally be incorporated into the cell wall, and accumulation of squalene. Generation of a large number of squalene containing vesicles in the cytoplasm may leach other lipids away from, and further weaken, the cell wall.
Near about 70% or more of the drug administered is absorbed and shows 40% biovailability. Maximum plasma concentration reaches in 2 hours of administration. When 250mg of drug was administered, the volume of distribution was found to be 947.5L. About 99% of the drug is bound to plasma protein mostly to serum albumin. Terbinafine is mainly metabolised by family of CYP enzymes. 80% of the metabolite is excreted in urine and remainder is excreted in feces. Half-life of terbinafine is 36 hours.
Common side effect includes:
Headache
Diarrhea
Rashes
Upset stomach
Abnormal liver function tests
Itching
Change in taste
Nausea
Should not be used in chronic or active liver diseases, lupus or renal impairment.
| Terbinafine HCL | 250 mg |