Drotaverine and Mefenamic Acid combination relieves abdominal pain and cramps. Drotaverine is an anti-spasmodic medicine which relieves contractions (spasms) associated with smooth muscles in the abdomen. Mefenamic Acid is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause abdominal pain and inflammation (swelling).
Abdominal pain and cramps
Spasmodic dysmenorrhoea
Colic pains including ureteric, biliary and intestinal colic.
Drotaverine is a spasmolytic agent by inhibiting PDE4 in smooth muscle cells. Drotaverine inhibits phosphodiesterases hydrolysing cAMP, thereby increasing cAMP concentration, decreasing Ca uptake of the cells and changing the distribution of calcium among the cells. It may also have minor allosteric calcium channel blocking properties.
Mefenamic acid, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). It exhibits anti-inflammatory, analgesic, and antipyretic activities. Similar to other NSAIDs, mefenamic acid inhibits prostaglandin synthetase. Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
Drotaverine: Bioavailability is highly variable with protein binding 80 to 95%. Metabolism is mainly hepatic with half-life equal to 7 to 12 hours.
Mefenamic acid: is rapidly absorbed after oral administration with the protein binding equal to 90%. Mefenamic acid undergoes metabolism by CYP2C9 to 3-hydroxymethyl mefenamic acid, and further oxidation to a 3-carboxymefenamic acid may occur. The fecal route of elimination accounts for up to 20% of the dose, mainly in the form of unconjugated 3-carboxymefenamic acid.3 The elimination half-life of mefenamic acid is approximately two hours. Mefenamic acid, its metabolites and conjugates are primarily excreted by the kidneys. Both renal and hepatic excretion are significant pathways of elimination.
Common side effect includes:
Nausea
Vomiting
Diarrhea
Stomach pain
Loss of appetite
Dryness in mouth
Feeling thirsty
Heartburn
Liver problems
Severe renal impairment
Peptic ulcers
Pregnancy
| Drotaverine | 80 mg |
| Mefenamic Acid | 250 mg |