Albendazole binds to the colchicine-sensitive site of tubulin causes degenerative alterations in the tegument and intestinal cells of the worm, thus inhibiting its polymerization or assembly into microtubules. Because of loss of the microtubules leads to inhibition of glucose uptake by the larval and adult stages of the parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies. It is poorly soluble in water therefore shows poor absorption. Plasma protein binding is found to be 70%. Metabolised in liver and is excreted in bile with a half-life of 8 to 12 hours.